The postgraduate courses were started in the University in 1978 leading to M.E. Degree, initially, in three branches. At present, courses are offered in the specialized fields of:

• Communication Systems and Networks
• Electronics System Engineering
• Telemedicine and eHealth System
• Information Technology
• Software Engineering
• Structural Engineering
• Public Health Engineering
• Telecommunication and Control Engineering
• Manufacturing Engineering
• Electrical Power Engineering
• Chemical Engineering
• Transportation Engineering
• Irrigation and Drainage Engineering
• Environmental Engineering & Management
• Geo-technical Engineering

Some courses are offered full time during the day while others are part-time conducted during the evenings. Sometimes, some particular course may be dropped in a given year because of non-availability of adequate number of students. The degrees to be awarded may be Post-graduate Diploma (P.G.D.), Master of Engineering (M.E.), Master of Philosophy (M.Phil.) or Doctor of Philosophy (Ph.D.); depending upon the quality and quantity of the research/work completed.

Post-graduate studies and research are organized by various departments as well as the following specialized institutes.

• Institute of Irrigation and Drainage Engineering
• Institute of Environmental Engineering and Management
• Institute of Petroleum & Natural Gas Engineering
• Institute of Information & Communication Technology
• Mehran University Institute of Science & Technology Development
• Directorate of Post-graduate Studies